Elected as the county seat of Bailey County in 1917, Muleshoe was named for the nearby Muleshoe Ranch. It was founded when the railway arrived in 1913. Muleshoe has always been the market and shipping center of the county. On the main street is a highly prized statue of a mule, a memorial to the animal's contributions in World War I. The oldest refuge in the state, Muleshoe National Wildlife Refuge is located twenty miles south of Muleshoe. It was founded in 1935 as a wintering area for migratory waterfowl. Annual events include the World Championship Muleshoe Pitching Contest on every 4th of July.
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