Santa Anna is a town in Coleman County in central Texas. It had 1.099 residents at the last census. The twin mesas were known as Santa Anna peaks before there was a town there. It was used as a camp for Texas Rangers and the town was officially established in 1906. The post office and a settlement were already set up for decades prior. Now, tourism is the biggest source of income for its residents and during the 20th century, the locals mostly worked in the oil industry. Every year on the third weekend in May, Santa Anna hosts the World Championship Bison Cook-off.